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The IL-1? Antibody Gevokizumab Limits Cardiac Remodeling and Coronary Dysfunction in Rats With Heart Failure.

ABSTRACT: This study reports preclinical data showing that the interleukin (IL)-1? modulation is a new promising target in the pathophysiological context of heart failure. Indeed, in nondiabetic Wistar and diabetic Goto-Kakizaki rats with chronic heart failure induced by myocardial infarction, administration of the IL-1? antibody gevokizumab improves 'surrogate' markers of survival (i.e., left ventricular remodeling, hemodynamics, and function as well as coronary function). However, whether IL-1? modulation per se or in combination with standard treatments of heart failure improves long-term outcome in human heart failure remains to be determined.

SUBMITTER: Harouki N

PROVIDER: S-EPMC6034492 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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The IL-1β Antibody Gevokizumab Limits Cardiac Remodeling and Coronary Dysfunction in Rats With Heart Failure.

Harouki Najah N Nicol Lionel L Remy-Jouet Isabelle I Henry Jean-Paul JP Dumesnil Anais A Lejeune Annie A Renet Sylvanie S Golding Francesca F Djerada Zoubir Z Wecker Didier D Bolduc Virginie V Bouly Muriel M Roussel Jerome J Richard Vincent V Mulder Paul P

JACC. Basic to translational science 20170828 4

This study reports preclinical data showing that the interleukin (IL)-1β modulation is a new promising target in the pathophysiological context of heart failure. Indeed, in nondiabetic Wistar and diabetic Goto-Kakizaki rats with chronic heart failure induced by myocardial infarction, administration of the IL-1β antibody gevokizumab improves 'surrogate' markers of survival (i.e., left ventricular remodeling, hemodynamics, and function as well as coronary function). However, whether IL-1β modulati ...[more]

PMID: 30062160

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