Ontology highlight
ABSTRACT:
SUBMITTER: Maifrede S
PROVIDER: S-EPMC6034642 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Maifrede Silvia S Nieborowska-Skorska Margaret M Sullivan-Reed Katherine K Dasgupta Yashodhara Y Podszywalow-Bartnicka Paulina P Le Bac Viet BV Solecka Martyna M Lian Zhaorui Z Belyaeva Elizaveta A EA Nersesyan Alina A Machnicki Marcin M MM Toma Monika M Chatain Nicolas N Rydzanicz Malgorzata M Zhao Huaqing H Jelinek Jaroslav J Piwocka Katarzyna K Sliwinski Tomasz T Stoklosa Tomasz T Ploski Rafal R Fischer Thomas T Sykes Stephen M SM Koschmieder Steffen S Bullinger Lars L Valent Peter P Wasik Mariusz A MA Huang Jian J Skorski Tomasz T
Blood 20180521 1
Mutations in FMS-like tyrosine kinase 3 (FLT3), such as internal tandem duplications (ITDs), can be found in up to 23% of patients with acute myeloid leukemia (AML) and confer a poor prognosis. Current treatment options for FLT3(ITD)-positive AMLs include genotoxic therapy and FLT3 inhibitors (FLT3i's), which are rarely curative. PARP1 inhibitors (PARP1i's) have been successfully applied to induce synthetic lethality in tumors harboring BRCA1/2 mutations and displaying homologous recombination ( ...[more]