Ontology highlight
ABSTRACT:
SUBMITTER: Yu S
PROVIDER: S-EPMC6035085 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Yu Shiyan S Tong Kevin K Zhao Yanlin Y Balasubramanian Iyshwarya I Yap George S GS Ferraris Ronaldo P RP Bonder Edward M EM Verzi Michael P MP Gao Nan N
Cell stem cell 20180607 1
Paneth cells are post-mitotic intestinal epithelial cells supporting the stem cell niche and mucosal immunity. Paneth cell pathologies are observed in various gastrointestinal diseases, but their plasticity and response to genomic and environmental challenges remain unclear. Using a knockin allele engineered at the mouse Lyz1 locus, we performed detailed Paneth cell-lineage tracing. Irradiation induced a subset of Paneth cells to proliferate and differentiate into villus epithelial cells. RNA se ...[more]