Ontology highlight
ABSTRACT:
SUBMITTER: Cho JH
PROVIDER: S-EPMC5705704 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Cho Jun-Hung JH Patel Bhaumik B Bonala Santosh S Manne Sasikanth S Zhou Yan Y Vadrevu Surya K SK Patel Jalpa J Peronaci Marco M Ghouse Shanawaz S Henske Elizabeth P EP Roegiers Fabrice F Giannikou Krinio K Kwiatkowski David J DJ Mansouri Hossein H Markiewski Maciej M MM White Brandon B Karbowniczek Magdalena M
Nature communications 20171129 1
Differentiation abnormalities are a hallmark of tuberous sclerosis complex (TSC) manifestations; however, the genesis of these abnormalities remains unclear. Here we report on mechanisms controlling the multi-lineage, early neuronal progenitor and neural stem-like cell characteristics of lymphangioleiomyomatosis (LAM) and angiomyolipoma cells. These mechanisms include the activation of a previously unreported Rheb-Notch-Rheb regulatory loop, in which the cyclic binding of Notch1 to the Notch-res ...[more]