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Silver-catalyzed remote Csp³-H functionalization of aliphatic alcohols.

ABSTRACT: Aliphatic alcohols are common and bulk chemicals in organic synthesis. The site-selective functionalization of non-activated aliphatic alcohols is attractive but challenging. Herein, we report a silver-catalyzed ?-selective Csp³-H bond functionalization of abundant and inexpensive aliphatic alcohols. Valuable oximonitrile substituted alcohols are easily obtained by using well-designed sulphonyl reagents under simple and mild conditions. This protocol realizes the challenging ?-selective C-C bond formation of simple alkanols.

SUBMITTER: Zhu Y

PROVIDER: S-EPMC6035238 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Silver-catalyzed remote Csp3-H functionalization of aliphatic alcohols.

Zhu Yuchao Y Huang Kaimeng K Pan Jun J Qiu Xu X Luo Xiao X Qin Qixue Q Wei Jialiang J Wen Xiaojin X Zhang Lizhi L Jiao Ning N

Nature communications 20180706 1

Aliphatic alcohols are common and bulk chemicals in organic synthesis. The site-selective functionalization of non-activated aliphatic alcohols is attractive but challenging. Herein, we report a silver-catalyzed δ-selective Csp3-H bond functionalization of abundant and inexpensive aliphatic alcohols. Valuable oximonitrile substituted alcohols are easily obtained by using well-designed sulphonyl reagents under simple and mild conditions. This protocol realizes the challenging δ-selecti ...[more]

PMID: 29980674

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