Unknown

Dataset Information

0

Construction of congested Csp3-Csp3 bonds by a formal Ni-catalyzed alkylboration.


ABSTRACT: Through the combination of a Ni-catalyzed alkene alkenylboration followed by hydrogenation, the synthesis of congested Csp3-Csp3-bonds can be achieved. Conditions have been identified that allow for the use of both alkenyl-bromides and -triflates. In addition, the hydrogenation creates another opportunity for stereocontrol, thus allowing access to multiple stereoisomers of the product. Finally, the method is demonstrated in the streamlined synthesis of a biologically relevant molecule.

SUBMITTER: Simlandy AK 

PROVIDER: S-EPMC8179681 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC5635847 | biostudies-literature
| S-EPMC9248350 | biostudies-literature
| S-EPMC8146735 | biostudies-literature
| S-EPMC4786957 | biostudies-literature
| S-EPMC6771483 | biostudies-literature
| S-EPMC6035238 | biostudies-literature
| S-EPMC4211291 | biostudies-literature
| S-EPMC7953840 | biostudies-literature
| S-EPMC7445163 | biostudies-literature
| S-EPMC5369400 | biostudies-literature