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Spherical Caps in Cell Polarization.

ABSTRACT: Intracellular symmetry breaking plays a key role in wide range of biological processes, both in single cells and in multicellular organisms. An important class of symmetry-breaking mechanisms relies on the cytoplasm/membrane redistribution of proteins that can autocatalytically promote their own recruitment to the plasma membrane. We present an analytical construction and a comprehensive parametric analysis of stable localized patterns in a reaction-diffusion model of such a mechanism in a spherical cell. The constructed patterns take the form of high-concentration patches localized into spherical caps, similar to the patterns observed in the studies of symmetry breaking in single cells and early embryos.

SUBMITTER: Diegmiller R

PROVIDER: S-EPMC6035301 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Spherical Caps in Cell Polarization.

Diegmiller Rocky R Montanelli Hadrien H Muratov Cyrill B CB Shvartsman Stanislav Y SY

Biophysical journal 20180620 1

Intracellular symmetry breaking plays a key role in wide range of biological processes, both in single cells and in multicellular organisms. An important class of symmetry-breaking mechanisms relies on the cytoplasm/membrane redistribution of proteins that can autocatalytically promote their own recruitment to the plasma membrane. We present an analytical construction and a comprehensive parametric analysis of stable localized patterns in a reaction-diffusion model of such a mechanism in a spher ...[more]

PMID: 29933887

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