Dataset Information

Quantitative MRI evaluation of glaucomatous changes in the visual pathway.

ABSTRACT:

Background

The aims of this study were to investigate glaucomatous morphological changes quantitatively in the visual cortex of the brain with voxel-based morphometry (VBM), a normalizing MRI technique, and to clarify the relationship between glaucomatous damage and regional changes in the visual cortex of patients with open-angle glaucoma (OAG).

Methods

Thirty-one patients with OAG (age: 55.9 ± 10.7, male: female = 9: 22) and 20 age-matched controls (age: 54.9 ± 9.8, male: female = 10: 10) were included in this study. The cross-sectional area (CSA) of the optic nerve was manually measured with T2-weighed MRI. Images of the visual cortex were acquired with T1-weighed 3D magnetization-prepared rapid acquisition with gradient echo (MPRAGE) sequencing, and the normalized regional visual cortex volume, i.e., gray matter density (GMD), in Brodmann areas (BA) 17, 18, and 19, was calculated with a normalizing technique based on statistic parametric mapping 8 (SPM8) analysis. We compared the regional GMD of the visual cortex in the control subjects and OAG patients. Spearman's rank correlation analysis was used to determine the relationship between optic nerve CSA and GMD in BA 17, 18, and 19.

Results

We found that the normal and OAG patients differed significantly in optic nerve CSA (p < 0.001) and visual cortex GMD in BA 17 (p = 0.030), BA 18 (p = 0.003), and BA 19 (p = 0.005). In addition, we found a significant correlation between optic nerve CSA and visual cortex GMD in BA 19 (r = 0.33, p = 0.023), but not in BA 17 (r = 0.17, p = 0.237) or BA 18 (r = 0.24, p = 0.099).

Conclusion

Quantitative MRI parametric evaluation of GMD can detect glaucoma-associated anatomical atrophy of the visual cortex in BA 17, 18, and 19. Furthermore, GMD in BA 19 was significantly correlated to the damage level of the optic nerve, as well as the retina, in patients with OAG. This is the first demonstration of an association between the cortex of the brain responsible for higher-order visual function and glaucoma severity. Evaluation of the visual cortex with MRI is thus a very promising potential method for objective examination in OAG.

SUBMITTER: Fukuda M

PROVIDER: S-EPMC6037347 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

Quantitative MRI evaluation of glaucomatous changes in the visual pathway.

Fukuda Mana M Omodaka Kazuko K Tatewaki Yasuko Y Himori Noriko N Matsudaira Izumi I Nishiguchi Koji M KM Murata Takaki T Taki Yasuyuki Y Nakazawa Toru T

PloS one 20180709 7

<h4>Background</h4>The aims of this study were to investigate glaucomatous morphological changes quantitatively in the visual cortex of the brain with voxel-based morphometry (VBM), a normalizing MRI technique, and to clarify the relationship between glaucomatous damage and regional changes in the visual cortex of patients with open-angle glaucoma (OAG).<h4>Methods</h4>Thirty-one patients with OAG (age: 55.9 ± 10.7, male: female = 9: 22) and 20 age-matched controls (age: 54.9 ± 9.8, male: female ...[more]

PMID: 29985921

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Project description:Importance:?-zone parapapillary atrophy (?PPA) has been reported as a risk factor for glaucoma onset and progression. Previous studies have shown that the prevalence of ?PPA differs between individuals of African descent (AD) and European descent (ED). Objective:To test whether the association between the presence and progression of ?PPA vs visual field progression of glaucoma differs between these 2 ancestry groups. Design, Setting, and Participants:In a prospective, multicenter, longitudinal cohort study, 634 individuals (1090 eyes) enrolled in the African Descent and Evaluation Study (ADAGES) with a diagnosis of glaucomatous optic neuropathy (GON) or ocular hypertension (OHT) and at least 2 disc stereophotographs were included. Two graders masked to clinical and ancestry data reviewed and graded the baseline and last disc stereophotographs for the presence of ?PPA at baseline and ?PPA progression (development or enlargement). Mixed-effects linear models were tested with visual field mean deviation as a dependent variable and time (alone and with interaction terms) as independent variables. ADAGES enrollment began in January 2003 and ended in July 2006; follow-up ended in 2016. Exposures:Disc stereophotographs. Main Outcomes and Measures:Progression of ?PPA in AD and ED individuals. Results:In 634 patients, a total of 814 eyes of AD (395 eyes) and ED (419) patients with GON and 276 eyes of AD (106) and ED (170) patients with OHT who were enrolled in ADAGES were analyzed. There were 336 (53.0%) women in the study; mean (SD) age was 61.9 (12.7) years. In the OHT group, the association between ?PPA at baseline and visual field progression was not significantly different between AD and ED eyes (??=?0.071; 95% CI, -0.016 to 0.158; P?=?.11), nor was the association between ?PPA progression and visual field progression (??=?0.020; 95% CI, -0.465 to 0.506; P?=?.93). In the GON group, ED eyes with baseline ?PPA progressed faster than did AD eyes with baseline ?PPA (??=?-0.124; 95% CI, -0.241 to -0.007; P?=?.04), although the association between ?PPA progression and visual field progression did not differ significantly between race groups (??=?-0.101; 95% CI, -0.323 to 0.119; P?=?.37). Conclusions and Relevance:Race had a significant effect on the association between baseline ?PPA and rates of visual field progression in eyes with GON. Progression of ?PPA was not associated with faster visual field progression in either racial group.

Dataset Information

Quantitative MRI evaluation of glaucomatous changes in the visual pathway.

Background

Methods

Results

Conclusion

Publications

Quantitative MRI evaluation of glaucomatous changes in the visual pathway.

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