Intra-operative spectroscopic assessment of surgical margins during breast conserving surgery.

ABSTRACT:

Background

In over 20% of breast conserving operations, postoperative pathological assessment of the excised tissue reveals positive margins, requiring additional surgery. Current techniques for intra-operative assessment of tumor margins are insufficient in accuracy or resolution to reliably detect small tumors. There is a distinct need for a fast technique to accurately identify tumors smaller than 1 mm² in large tissue surfaces within 30 min.

Methods

Multi-modal spectral histopathology (MSH), a multimodal imaging technique combining tissue auto-fluorescence and Raman spectroscopy was used to detect microscopic residual tumor at the surface of the excised breast tissue. New algorithms were developed to optimally utilize auto-fluorescence images to guide Raman me

SUBMITTER: Shipp DW 

PROVIDER: S-EPMC6038277 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature