Dataset Information
Breast-shape changes during radiation therapy after breast-conserving surgery.
Ontology highlight
ABSTRACT: Background & purpose
With the introduction of more conformal techniques for breast cancer radiation therapy (RT), motion management is becoming increasingly important. We studied the breast-shape variability during RT after breast-conserving surgery (BCS).Materials & methods
Planning computed tomography (CT) and follow-up cone-beam CT (CBCT) scans were available for 71 fractions of 17 patients undergoing RT after BCS. First, the CT and the CBCT scans were registered on bones. Subsequently, breast-contour data were generated. The CBCT contours were analyzed in 3D in terms of deviations (mean and standard deviation) relative to the contour of the CT scan for the upper medial, lower medial, upper lateral, and lower lateral breast quadrants, and the axilla.Results
Regional systematic and random standard deviations of the breast quadrants varied between 1.5 and 2.1?mm and 1.0-1.6?mm, respectively, and were larger for the axilla (3.0?mm). An absolute average shape change of ??4.0?mm in at least one region was present in 21/71 fractions (30%), predominantly in breast volumes?>?800?cc (p?=?<0.01). Furthermore, seroma was associated with larger shape changes (p?=?0.04).Conclusions
Breast-shape variability varies between anatomic locations. Changes in the order of 4?mm are frequently observed during RT, especially for large breasts. This should be taken into account in the development of protocols for partial breast irradiation and boost treatment.
SUBMITTER: Alderliesten T
PROVIDER: S-EPMC7807602 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
Breast-shape changes during radiation therapy after breast-conserving surgery.
Physics and imaging in radiation oncology 20180401
<h4>Background & purpose</h4>With the introduction of more conformal techniques for breast cancer radiation therapy (RT), motion management is becoming increasingly important. We studied the breast-shape variability during RT after breast-conserving surgery (BCS).<h4>Materials & methods</h4>Planning computed tomography (CT) and follow-up cone-beam CT (CBCT) scans were available for 71 fractions of 17 patients undergoing RT after BCS. First, the CT and the CBCT scans were registered on bones. Sub ...[more]