A new crystal form and anti-microbial activity of (E)-1-[3-(2-hy-droxy-benzyl-idene-amino)-phen-yl]ethanone.

ABSTRACT: The title Schiff base compound, C₁₅H₁₃NO₂, crystallizes in a new crystal form in the space group P2₁2₁2₁, which is different from the monoclinic P2₁/n space group reported previously [De et al. (2009 ?). Indian J. Chem. Sect. B, 48, 595-598]. An intra-molecular O-H?N hydrogen bond occurs between the hy-droxy and azomethine moieties. In the crystal, mol-ecules are linked by weak C-H?O hydrogen bonds into supra-molecular chains propagating along the b-axis direction with a C(8) graph-set motif. The contribution of these two contacts in Hirshfeld surface area are around 19 and 21%, respectively. The title compound was screened for its anti-bacterial activity against two gram-negative (Escherichia coli and Salmonella typhimurium) and one gram-positive (Staphyloccus aureus) bacteria. The results of this study reveal that this Schiff base shows good activity against only one bacterium, i.e. Salmonella typhimurium.

SUBMITTER: Moussa Slimane N 

PROVIDER: S-EPMC6038618 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature