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Pd(II)-Catalyzed Enantioselective C(sp3)-H Arylation of Free Carboxylic Acids.

ABSTRACT: A monoprotected aminoethyl amine chiral ligand based on an ethylenediamine backbone was developed to achieve Pd-catalyzed enantioselective C(sp3)-H arylation of cyclopropanecarboxylic and 2-aminoisobutyric acids without using exogenous directing groups. This new chiral catalyst affords new disconnection for preparing diverse chiral carboxylic acids from simple starting materials that are complementary to the various ring forming approaches.

SUBMITTER: Shen PX 

PROVIDER: S-EPMC6038808 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Pd(II)-Catalyzed Enantioselective C(sp<sup>3</sup>)-H Arylation of Free Carboxylic Acids.

Shen Peng-Xiang PX   Hu Liang L   Shao Qian Q   Hong Kai K   Yu Jin-Quan JQ  

Journal of the American Chemical Society 20180517 21

A monoprotected aminoethyl amine chiral ligand based on an ethylenediamine backbone was developed to achieve Pd-catalyzed enantioselective C(sp<sup>3</sup>)-H arylation of cyclopropanecarboxylic and 2-aminoisobutyric acids without using exogenous directing groups. This new chiral catalyst affords new disconnection for preparing diverse chiral carboxylic acids from simple starting materials that are complementary to the various ring forming approaches. ...[more]

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