Ontology highlight
ABSTRACT:
SUBMITTER: Chakraborty AA
PROVIDER: S-EPMC6039096 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Science translational medicine 20170701 398
Inactivation of the von Hippel-Lindau tumor suppressor protein (pVHL) is the signature lesion in the most common form of kidney cancer, clear cell renal cell carcinoma (ccRCC). pVHL loss causes the transcriptional activation of hypoxia-inducible factor (HIF) target genes, including many genes that encode histone lysine demethylases. Moreover, chromatin regulators are frequently mutated in this disease. We found that ccRCC displays increased H3K27 acetylation and a shift toward mono- or unmethyla ...[more]