Ontology highlight
ABSTRACT:
SUBMITTER: Nicholson HE
PROVIDER: S-EPMC6913182 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Nicholson Hilary E HE Tariq Zeshan Z Housden Benjamin E BE Jennings Rebecca B RB Stransky Laura A LA Perrimon Norbert N Signoretti Sabina S Kaelin William G WG
Science signaling 20191001 601
Inactivation of the <i>VHL</i> tumor suppressor gene is the signature initiating event in clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer, and causes the accumulation of hypoxia-inducible factor 2α (HIF-2α). HIF-2α inhibitors are effective in some ccRCC cases, but both de novo and acquired resistance have been observed in the laboratory and in the clinic. Here, we identified synthetic lethality between decreased activity of cyclin-dependent kinases 4 and 6 (CDK4/6) ...[more]