Ontology highlight
ABSTRACT:
SUBMITTER: Wong GS
PROVIDER: S-EPMC6039276 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Wong Gabrielle S GS Zhou Jin J Liu Jie Bin JB Wu Zhong Z Xu Xinsen X Li Tianxia T Xu David D Schumacher Steven E SE Puschhof Jens J McFarland James J Zou Charles C Dulak Austin A Henderson Les L Xu Peng P O'Day Emily E Rendak Rachel R Liao Wei-Li WL Cecchi Fabiola F Hembrough Todd T Schwartz Sarit S Szeto Christopher C Rustgi Anil K AK Wong Kwok-Kin KK Diehl J Alan JA Jensen Karin K Graziano Francesco F Ruzzo Annamaria A Fereshetian Shaunt S Mertins Philipp P Carr Steven A SA Beroukhim Rameen R Nakamura Kenichi K Oki Eiji E Watanabe Masayuki M Baba Hideo H Imamura Yu Y Catenacci Daniel D Bass Adam J AJ
Nature medicine 20180528 7
The role of KRAS, when activated through canonical mutations, has been well established in cancer<sup>1</sup>. Here we explore a secondary means of KRAS activation in cancer: focal high-level amplification of the KRAS gene in the absence of coding mutations. These amplifications occur most commonly in esophageal, gastric and ovarian adenocarcinomas<sup>2-4</sup>. KRAS-amplified gastric cancer models show marked overexpression of the KRAS protein and are insensitive to MAPK blockade owing to thei ...[more]