Differentiation of Normal and Radioresistant Prostate Cancer Xenografts Using Magnetization Transfer-Prepared MRI.

ABSTRACT: The ability of MRI to differentiate between normal and radioresistant cancer was investigated in prostate tumour xenografts in mice. Specifically, the process of magnetization exchange between water and other molecules was studied. It was found that magnetization transfer from semisolid macromolecules (MT) and chemical exchange saturation transfer (CEST) combined were significantly different between groups (p < 0.01). Further, the T₂ relaxation of the semisolid macromolecular pool (T_2,B), a parameter specific to MT, was found to be significantly different (p < 0.01). Also significantly different were the rNOE contributions associated with methine groups at -0.9 ppm with a saturation B₁ of 0.5 µT (p < 0.01) and with other aliphatic groups at -3.3 ppm with 0.

SUBMITTER: Lam WW 

PROVIDER: S-EPMC6041323 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature