Differentiation of Normal and Radioresistant Prostate Cancer Xenografts Using Magnetization Transfer-Prepared MRI.
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ABSTRACT:
SUBMITTER: Lam WW
PROVIDER: S-EPMC6041323 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Differentiation of Normal and Radioresistant Prostate Cancer Xenografts Using Magnetization Transfer-Prepared MRI.
Lam Wilfred W WW Oakden Wendy W Murray Leedan L Klein Jonathan J Iorio Caterina C Screaton Robert A RA Koletar Margaret M MM Chu William W Liu Stanley K SK Stanisz Greg J GJ
Scientific reports 20180711 1
The ability of MRI to differentiate between normal and radioresistant cancer was investigated in prostate tumour xenografts in mice. Specifically, the process of magnetization exchange between water and other molecules was studied. It was found that magnetization transfer from semisolid macromolecules (MT) and chemical exchange saturation transfer (CEST) combined were significantly different between groups (p < 0.01). Further, the T<sub>2</sub> relaxation of the semisolid macromolecular pool (T< ...[more]
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