Ontology highlight
ABSTRACT:
SUBMITTER: Bernardini C
PROVIDER: S-EPMC6042022 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Bernardini C C Lattanzi W W Businaro R R Leone S S Corvino V V Sorci G G Lauro G G Fumagalli L L Donato F R FR Michetti F F
Gene expression 20100101 6
S100B is a Ca2+ binding protein mainly secreted by astrocytes in the vertebrate brain that is considered a multifunctional cytokine and/or a damage-associated molecular pattern (DAMP) protein and a marker of brain injury and neurodegeneration when measured in different body fluids. It has been widely shown that this protein can exert diverse effects in neural cultures depending on its concentration, having detrimental effects at micromolar concentrations. The molecular mechanisms underlying this ...[more]