Ontology highlight
ABSTRACT:
SUBMITTER: Shen E
PROVIDER: S-EPMC6042103 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Shen Erxia E Wang Qin Q Rabe Hardis H Liu Wenquan W Cantor Harvey H Leavenworth Jianmei W JW
Proceedings of the National Academy of Sciences of the United States of America 20180611 26
Lineage commitment and differentiation into CD4<sup>+</sup> T cell subsets reflect an interplay between chromatin regulators and transcription factors (TF). Follicular T cell development is regulated by the Bcl6 TF, which helps determine the phenotype and follicular localization of both CD4<sup>+</sup> follicular helper T cells (T<sub>FH</sub>) and follicular regulatory T cells (T<sub>FR</sub>). Here we show that Bcl6-dependent control of follicular T cells is mediated by a complex formed betwee ...[more]