Dataset Information

Women's prepregnancy lipid levels and number of children: a Norwegian prospective population-based cohort study.

ABSTRACT:

Objective

To study prepregnancy serum lipid levels and the association with the number of children.

Design

Prospective, population-based cohort.

Setting

Linked data from the Cohort of Norway and the Medical Birth Registry of Norway.

Participants

2645 women giving birth to their first child during 1994-2003 (488 one-child mothers and 2157 women with ?2 births) and 1677 nulliparous women.

Main outcome measures

ORs for no and one lifetime pregnancy (relative to ?2 pregnancies) obtained by multinomial logistic regression, adjusted for age at examination, education, body mass index (BMI), smoking, time since last meal and oral contraceptive use.

Results

Assessed in quintiles, higher prepregnant triglyceride (TG) and TG to high-density lipoprotein (TG:HDL-c) ratio levels were associated with increased risk of one lifetime pregnancy compared with having ?2 children. Compared with the highest quintile, women in the lowest quintile of HDL cholesterol levels had an increased risk of one lifetime pregnancy (OR 1.7, 95%?CI 1.2 to 2.4), as were women with the highest low-density lipoprotein (LDL) cholesterol, TG and TG:HDL-c ratio quintiles (compared with the lowest) (OR 1.2, 95%?CI 0.8 to 1.7; OR 2.2, 95%?CI 1.5 to 3.2; and OR 2.2, 95%?CI 1.5 to 3.2, respectively). Similar effects were found in women with BMI?25?and the highest LDL and total cholesterol levels in risk of lifetime nulliparity.

Conclusion

Women with unfavourable prepregnant lipid profile had higher risk of having no or only one child. These findings substantiate an association between prepregnant serum lipid levels and number of children. Previously observed associations between low parity and increased cardiovascular mortality may in part be due to pre-existing cardiovascular disease lipid risk factors.

SUBMITTER: Pirnat A

PROVIDER: S-EPMC6042606 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Women's prepregnancy lipid levels and number of children: a Norwegian prospective population-based cohort study.

Pirnat Aleksandra A DeRoo Lisa A LA Skjærven Rolv R Morken Nils-Halvdan NH

BMJ open 20180709 6

<h4>Objective</h4>To study prepregnancy serum lipid levels and the association with the number of children.<h4>Design</h4>Prospective, population-based cohort.<h4>Setting</h4>Linked data from the Cohort of Norway and the Medical Birth Registry of Norway.<h4>Participants</h4>2645 women giving birth to their first child during 1994-2003 (488 one-child mothers and 2157 women with ≥2 births) and 1677 nulliparous women.<h4>Main outcome measures</h4>ORs for no and one lifetime pregnancy (relative to ≥ ...[more]

PMID: 29986867

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Dataset Information

Women's prepregnancy lipid levels and number of children: a Norwegian prospective population-based cohort study.

Objective

Design

Setting

Participants

Main outcome measures

Results

Conclusion

Publications

Women's prepregnancy lipid levels and number of children: a Norwegian prospective population-based cohort study.

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