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A hierarchical Bayesian model to predict APOE4 genotype and the age of Alzheimer's disease onset.

ABSTRACT: In this work we use a hierarchical Bayesian paradigm to introduce a theoretical framework to determine an individual's Apolipoprotein ?4 (APOE4) genotype, which heavily influences both the age of onset and probability of acquiring Alzheimer's disease (AD). This calculation is based solely on an individual's family history. This APOE4 genotype estimation is then combined with a number of known factors that influence AD onset to produce a function that estimates the onset of AD as a function of age. We disseminated our Alzheimer's predictive tool online at http://www.alzheimerspredictor.com.

SUBMITTER: Hane F 

PROVIDER: S-EPMC6042730 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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A hierarchical Bayesian model to predict APOE4 genotype and the age of Alzheimer's disease onset.

Hane Francis F   Augusta Carolyn C   Bai Owen O  

PloS one 20180712 7

In this work we use a hierarchical Bayesian paradigm to introduce a theoretical framework to determine an individual's Apolipoprotein ε4 (APOE4) genotype, which heavily influences both the age of onset and probability of acquiring Alzheimer's disease (AD). This calculation is based solely on an individual's family history. This APOE4 genotype estimation is then combined with a number of known factors that influence AD onset to produce a function that estimates the onset of AD as a function of ag  ...[more]

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