Ontology highlight
ABSTRACT:
SUBMITTER: Rauhamaki S
PROVIDER: S-EPMC6044741 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
ACS omega 20180611 6
Retinoic acid-related orphan receptor γt (RORγt) has a vital role in the differentiation of T-helper 17 (TH17) cells. Potent and specific RORγt inverse agonists are sought for treating TH17-related diseases such as psoriasis, rheumatoid arthritis, and type 1 diabetes. Here, the aim was to discover novel RORγt ligands using both standard molecular docking and negative image-based screening. Interestingly, both of these in silico techniques put forward mostly the same compounds for experimental te ...[more]