Ontology highlight
ABSTRACT:
SUBMITTER: Tome S
PROVIDER: S-EPMC6842800 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Tome Saki S Sasaki Tetsuya T Takahashi Satoru S Takei Yosuke Y
Experimental animals 20190610 4
T helper 17 (Th17) cells have been suggested to play a crucial role in various complications during pregnancy by participating in maternal immune activation (MIA). To test a possible role for Th17 cells in MIA-mediated abortion, we analyzed transgenic mice overexpressing retinoic acid receptor-related orphan receptor gamma-t (RORγt), a master regulator of IL-17 producing cell development. These mutant mice (RORγt Tg mice) exhibited a constitutive upregulation of serum IL-17A and decreased E-cadh ...[more]