Ontology highlight
ABSTRACT:
SUBMITTER: Patil S
PROVIDER: S-EPMC6044916 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Patil Sohan S Kuman Meenu Mahesh MM Palvai Sandeep S Sengupta Poulomi P Basu Sudipta S
ACS omega 20180202 2
Mitochondrion has emerged as one of the unconventional targets in next-generation cancer therapy. Hence, small molecules targeting mitochondria in cancer cells have immense potential in the next-generation anticancer therapeutics. In this report, we have synthesized a library of hydrazide-hydrazone-based small molecules and identified a novel compound that induces mitochondrial outer membrane permeabilization by inhibiting antiapoptotic B-cell CLL/lymphoma 2 (Bcl-2) family proteins followed by s ...[more]