Ontology highlight
ABSTRACT:
SUBMITTER: Chirakul S
PROVIDER: S-EPMC6045580 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Chirakul Sunisa S Norris Michael H MH Pagdepanichkit Sirawit S Somprasong Nawarat N Randall Linnell B LB Shirley James F JF Borlee Bradley R BR Lomovskaya Olga O Tuanyok Apichai A Schweizer Herbert P HP
Scientific reports 20180713 1
Therapy of Burkholderia pseudomallei acute infections is largely limited to a few β-lactam antibiotics such as ceftazidime or meropenem. Although relatively rare, resistance emergence during therapy leads to treatment failures with high mortality rates. In the absence of acquired external resistance determinants in B. pseudomallei emergence of β-lactam resistance is invariably caused by mutational modification of genomically encoded factors. These include the deletion of the ceftazidime target p ...[more]