Ontology highlight
ABSTRACT:
SUBMITTER: Wolfman SL
PROVIDER: S-EPMC6045623 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Wolfman Shannon L SL Gill Daniel F DF Bogdanic Fili F Long Katie K Al-Hasani Ream R McCall Jordan G JG Bruchas Michael R MR McGehee Daniel S DS
Nature communications 20180713 1
Nicotine use can lead to dependence through complex processes that are regulated by both its rewarding and aversive effects. Recent studies show that aversive nicotine doses activate excitatory inputs to the interpeduncular nucleus (IPN) from the medial habenula (MHb), but the downstream targets of the IPN that mediate aversion are unknown. Here we show that IPN projections to the laterodorsal tegmentum (LDTg) are GABAergic using optogenetics in tissue slices from mouse brain. Selective stimulat ...[more]