Ontology highlight
ABSTRACT:
SUBMITTER: Zak JD
PROVIDER: S-EPMC6045664 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Scientific reports 20180713 1
The calcium-activated chloride channel anoctamin-2 (Ano2) is thought to amplify transduction currents in olfactory receptor neurons (ORNs), a hypothesis supported by previous studies in dissociated neurons from Ano2<sup>-/-</sup> mice. Paradoxically, despite a reduction in transduction currents in Ano2<sup>-/-</sup> ORNs, their spike output for odor stimuli may be higher. We examined the role of Ano2 in ORNs in their native environment in freely breathing mice by imaging activity in ORN axons as ...[more]