Dataset Information

Prognostic Impact of CEACAM1 in Node-Negative Ovarian Cancer Patients.

ABSTRACT: The underlying mechanisms of ovarian cancer (OvCa) dissemination are still poorly understood, and novel molecular markers for this cancer type are urgently needed. In search of adhesion molecules with prognostic relevance in OvCa, we compared tumors with good outcome (alive?>?3 years) and those with poor outcome (dead?n = 517) as well as CEACAM1 protein expression by Western blot analysis in a cohort of 242 tumor samples. Further, CEACAM1 localization in tumour tissue was evaluated by immunohistochemistry and CEACAM1 splice variants by RT-PCR in representative tumours. In Kaplan-Meier analysis, high CEACAM1 mRNA levels significantly correlated with longer survival (p = 0.008). By Western blot analysis in the second cohort, similar associations of high CEACAM1 protein levels with longer recurrence-free survival (RFS, p = 0.035) and overall survival (OAS, p = 0.004) were observed. In multivariate Cox regression analysis including clinical prognostic parameters, CEACAM1 mRNA or protein expression turned out as independent prognostic markers. Stratified survival analysis showed that high CEACAM1 protein expression was prognostic in node-negative tumors (p = 0.045 and p = 0.0002 for DFS and OAS) but lost prognostic significance in node-positive carcinomas. Similarly, high CEACAM1 mRNA expression did not show prognostic relevance in tumors with lymphatic invasion (L1) but was associated with longer survival in cases without lymphovascular involvement. Further analysis showed a predominance of 4S and 4L isoforms and mostly membraneous CEACAM1 localization in ovarian tumours. Our results suggest that CEACAM1 might be an independent favorable prognostic marker in OvCa, especially in the subgroup of patients with solely intraperitoneal metastasis.

SUBMITTER: Oliveira-Ferrer L

PROVIDER: S-EPMC6046165 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Prognostic Impact of CEACAM1 in Node-Negative Ovarian Cancer Patients.

Oliveira-Ferrer Leticia L Goswami Roshni R Galatenko Vladimir V Ding Yi Y Eylmann Kathrin K Legler Karen K Kürti Sascha S Schmalfeldt Barbara B Milde-Langosch Karin K

Disease markers 20180628

The underlying mechanisms of ovarian cancer (OvCa) dissemination are still poorly understood, and novel molecular markers for this cancer type are urgently needed. In search of adhesion molecules with prognostic relevance in OvCa, we compared tumors with good outcome (alive > 3 years) and those with poor outcome (dead < 2 years) within data from The Cancer Genome Atlas (TCGA). The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) turned out as the only gene with differential ex ...[more]

PMID: 30050594

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Dataset Information

Prognostic Impact of CEACAM1 in Node-Negative Ovarian Cancer Patients.

Publications

Prognostic Impact of CEACAM1 in Node-Negative Ovarian Cancer Patients.

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