Ontology highlight
ABSTRACT:
SUBMITTER: David BP
PROVIDER: S-EPMC6047048 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20180517 7
Matrix assisted laser desorption ionization time-of-flight (MALDI-TOF) imaging mass spectrometry has emerged as a powerful, label-free technique to visualize penetration of small molecules <i>in vivo</i> and <i>in vitro</i>, including in 3D cell culture spheroids; however, some spheroids do not grow sufficiently large to provide enough area for imaging mass spectrometry. Here, we describe an <i>ex vivo</i> method for visualizing unlabeled peptides and small molecules in tumor explants, which can ...[more]