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Mass Spectrometry-Based Visualization of Molecules Associated with Human Habitats.


ABSTRACT: The cars we drive, the homes we live in, the restaurants we visit, and the laboratories and offices we work in are all a part of the modern human habitat. Remarkably, little is known about the diversity of chemicals present in these environments and to what degree molecules from our bodies influence the built environment that surrounds us and vice versa. We therefore set out to visualize the chemical diversity of five built human habitats together with their occupants, to provide a snapshot of the various molecules to which humans are exposed on a daily basis. The molecular inventory was obtained through untargeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of samples from each human habitat and from the people that occupy those habitats. Mapping MS-derived data onto 3D models of the environments showed that frequently touched surfaces, such as handles (e.g., door, bicycle), resemble the molecular fingerprint of the human skin more closely than other surfaces that are less frequently in direct contact with humans (e.g., wall, bicycle frame). Approximately 50% of the MS/MS spectra detected were shared between people and the environment. Personal care products, plasticizers, cleaning supplies, food, food additives, and even medications that were found to be a part of the human habitat. The annotations indicate that significant transfer of chemicals takes place between us and our built environment. The workflows applied here will lay the foundation for future studies of molecular distributions in medical, forensic, architectural, space exploration, and environmental applications.

SUBMITTER: Petras D 

PROVIDER: S-EPMC6326777 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Mass Spectrometry-Based Visualization of Molecules Associated with Human Habitats.

Petras Daniel D   Nothias Louis-Félix LF   Quinn Robert A RA   Alexandrov Theodore T   Bandeira Nuno N   Bouslimani Amina A   Castro-Falcón Gabriel G   Chen Liangyu L   Dang Tam T   Floros Dimitrios J DJ   Hook Vivian V   Garg Neha N   Hoffner Nicole N   Jiang Yike Y   Kapono Clifford A CA   Koester Irina I   Knight Rob R   Leber Christopher A CA   Ling Tie-Jun TJ   Luzzatto-Knaan Tal T   McCall Laura-Isobel LI   McGrath Aaron P AP   Meehan Michael J MJ   Merritt Jonathan K JK   Mills Robert H RH   Morton Jamie J   Podvin Sonia S   Protsyuk Ivan I   Purdy Trevor T   Satterfield Kendall K   Searles Stephen S   Shah Sahil S   Shires Sarah S   Steffen Dana D   White Margot M   Todoric Jelena J   Tuttle Robert R   Wojnicz Aneta A   Sapp Valerie V   Vargas Fernando F   Yang Jin J   Zhang Chao C   Dorrestein Pieter C PC  

Analytical chemistry 20161024 22


The cars we drive, the homes we live in, the restaurants we visit, and the laboratories and offices we work in are all a part of the modern human habitat. Remarkably, little is known about the diversity of chemicals present in these environments and to what degree molecules from our bodies influence the built environment that surrounds us and vice versa. We therefore set out to visualize the chemical diversity of five built human habitats together with their occupants, to provide a snapshot of t  ...[more]

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