Ontology highlight
ABSTRACT:
SUBMITTER: Melis C
PROVIDER: S-EPMC6047168 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Melis Claudia C Distinto Simona S Bianco Giulia G Meleddu Rita R Cottiglia Filippo F Fois Benedetta B Taverna Domenico D Angius Rossella R Alcaro Stefano S Ortuso Francesco F Gaspari Marco M Angeli Andrea A Del Prete Sonia S Capasso Clemente C Supuran Claudiu T CT Maccioni Elias E
ACS medicinal chemistry letters 20180606 7
A small library of psoralen carboxylic acids and their corresponding benzenesulfonamide derivatives were designed and synthesized to evaluate their activity and selectivity toward tumor associated human carbonic anhydrase (hCA) isoforms IX and XII. Both psoralen acids and sulfonamides exhibited potent inhibition of IX and XII isozymes in the nanomolar concentration range. However, psoralen acids resulted as the most selective in comparison with the corresponding benzenesulfonamide derivatives. O ...[more]