Ontology highlight
ABSTRACT:
SUBMITTER: Elster N
PROVIDER: S-EPMC6047239 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Elster Naomi N Toomey Sinead S Fan Yue Y Cremona Mattia M Morgan Clare C Weiner Gorzel Karolina K Bhreathnach Una U Milewska Malgorzata M Murphy Madeline M Madden Stephen S Naidoo Jarushka J Fay Joanna J Kay Elaine E Carr Aoife A Kennedy Sean S Furney Simon S Mezynski Janusz J Breathhnach Oscar O Morris Patrick P Grogan Liam L Hill Arnold A Kennedy Susan S Crown John J Gallagher William W Hennessy Bryan B Eustace Alex A
Therapeutic advances in medical oncology 20180713
<h4>Background</h4>Somatic mutations in the <i>ERBB</i> genes (epidermal growth factor receptor: <i>EGFR, ERBB2, ERBB3, ERBB4</i>) promote oncogenesis and lapatinib resistance in metastatic HER2+ (human epidermal growth factor-like receptor 2) breast cancer <i>in vitro</i>. Our study aimed to determine the frequency of mutations in four genes: <i>EGFR, ERBB2, ERBB3</i> and <i>ERBB4</i> and to investigate whether these mutations affect cellular behaviour and therapy response <i>in vitro</i> and o ...[more]