Mimicry of a ?-Hairpin Turn by a Nonpeptidic Laterally Flexible Foldamer.
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ABSTRACT:
SUBMITTER: Meisel JW
PROVIDER: S-EPMC6047514 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Mimicry of a β-Hairpin Turn by a Nonpeptidic Laterally Flexible Foldamer.
Meisel Joseph W JW Hu Chunhua T CT Hamilton Andrew D AD
Organic letters 20180613 13
The design and characterization of a proteomimetic foldamer that displays lateral flexibility endowed by intramolecular bifurcated hydrogen bonds is reported. The MAMBA scaffold, derived from meta-aminomethylbenzoic acid, adopts a serpentine conformation that mimics the side chain projection of all four residues in a β-hairpin turn. ...[more]
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