Adiposity and risks of colorectal and small intestine cancer in Chinese adults: a prospective study of 0.5 million people.

ABSTRACT:

Background

Uncertainty remains about the associations of adiposity with intestinal cancer in China and by its anatomical subtype.

Methods

The prospective China Kadoorie Biobank recorded 3024 incident cases of colorectal (CRC) and 143 cases of small intestine (SIC) cancer during a 10-year follow-up among 509 568 participants without prior cancer at baseline. Cox regression was used to estimate adjusted hazard ratios (HRs) for specific cancers associated with adiposity.

Results

Overall mean body mass index (BMI) was 23.7  kg/m². BMI was positively associated with CRC (HR per SD 1.10 [95% CI 1.06-1.14]), colon (1.13 [1.07-1.18]), and rectal (1.07 [1.02-1.13]) cancer. For waist circumference, the corresponding HRs per SD were 1.14 (1.10-1.18), 1.18 (1.13-1.24),

SUBMITTER: Pang Y 

PROVIDER: S-EPMC6048138 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature