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IL-4R? Polymorphism Is Associated With Myasthenia Gravis in Chinese Han Population.

ABSTRACT: Interleukin-4 (IL-4) is a potent growth and differentiation factor for B cells which play a vital role in the pathogenesis of myasthenia gravis (MG). IL-4 exerts its function by binding to three types of IL-4 receptor (IL-4R) complexes. IL-4R? is the key component of the IL-4R complex. We hypothesize that polymorphism of IL-4R? gene may be associated with the susceptibility and severity of MG. A Chinese cohort of 480 MG patients and 487 healthy controls were recruited. Polymorphisms of IL-4R? gene were determined with SNPscan™ methods and compared between MG and control groups, as well as among MG subgroups. Rs2107356 and rs1805010 were found to be associated with adult thymoma associated MG, and rs1801275 was found to be associated with adult non-thymoma AChR-Ab positive MG. We did not found association between IL-4R? polymorphism and the severity of MG. Genetic variations of IL-4R? were found associated with the susceptibility of MG in Chinese Han population.

SUBMITTER: Jiang P 

PROVIDER: S-EPMC6048264 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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IL-4Rα Polymorphism Is Associated With Myasthenia Gravis in Chinese Han Population.

Jiang Ping P   Yue Yao-Xian YX   Hong Yu Y   Xie Yanchen Y   Gao Xiang X   Gu Chuan-Kai CK   Hao Hong-Jun HJ   Qin Yue Y   Ding Xiao-Jun XJ   Song Min M   Li Hai-Feng HF   Zhang Xu X  

Frontiers in neurology 20180710

Interleukin-4 (IL-4) is a potent growth and differentiation factor for B cells which play a vital role in the pathogenesis of myasthenia gravis (MG). IL-4 exerts its function by binding to three types of IL-4 receptor (IL-4R) complexes. IL-4Rα is the key component of the IL-4R complex. We hypothesize that polymorphism of IL-4Rα gene may be associated with the susceptibility and severity of MG. A Chinese cohort of 480 MG patients and 487 healthy controls were recruited. Polymorphisms of IL-4Rα ge  ...[more]

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