Ontology highlight
ABSTRACT:
SUBMITTER: Iyer G
PROVIDER: S-EPMC6049398 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Iyer Gopa G Balar Arjun V AV Milowsky Matthew I MI Bochner Bernard H BH Dalbagni Guido G Donat S Machele SM Herr Harry W HW Huang William C WC Huang William C WC Taneja Samir S SS Woods Michael M Ostrovnaya Irina I Al-Ahmadie Hikmat H Arcila Maria E ME Riches Jamie C JC Meier Andreas A Bourque Caitlin C Shady Maha M Won Helen H Rose Tracy L TL Kim William Y WY Kania Brooke E BE Boyd Mariel E ME Cipolla Catharine K CK Regazzi Ashley M AM Delbeau Daniela D McCoy Asia S AS Vargas Hebert Alberto HA Berger Michael F MF Solit David B DB Rosenberg Jonathan E JE Bajorin Dean F DF
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20180509 19
Purpose Neoadjuvant chemotherapy followed by radical cystectomy (RC) is a standard of care for the management of muscle-invasive bladder cancer (MIBC). Dose-dense cisplatin-based regimens have yielded favorable outcomes compared with standard-dose chemotherapy, yet the optimal neoadjuvant regimen remains undefined. We assessed the efficacy and tolerability of six cycles of neoadjuvant dose-dense gemcitabine and cisplatin (ddGC) in patients with MIBC. Patients and Methods In this prospective, mul ...[more]