Ontology highlight
ABSTRACT:
SUBMITTER: Schafer A
PROVIDER: S-EPMC6049513 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Schäfer Andrea A Mekker Bernadette B Mallick Medhavi M Vastolo Viviana V Karaulanov Emil E Sebastian Dominik D von der Lippen Carina C Epe Bernd B Downes Damien J DJ Scholz Carola C Niehrs Christof C
Genes & development 20180608 11-12
Changes in DNA methylation are among the best-documented epigenetic alterations accompanying organismal aging. However, whether and how altered DNA methylation is causally involved in aging have remained elusive. GADD45α (growth arrest and DNA damage protein 45A) and ING1 (inhibitor of growth family member 1) are adapter proteins for site-specific demethylation by TET (ten-eleven translocation) methylcytosine dioxygenases. Here we show that <i>Gadd45a/Ing1</i> double-knockout mice display segmen ...[more]