Ontology highlight
ABSTRACT:
SUBMITTER: Spears RJ
PROVIDER: S-EPMC6049525 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Chemical science 20180531 25
The bioconjugation of proteins with small molecules has proved an invaluable strategy for probing and perturbing biological mechanisms. The general use of chemical methods for protein functionalisation can be limited however by the requirement for complicated reaction partners to be present in large excess, and harsh conditions which are incompatible with many protein scaffolds. Herein we describe a site-selective organocatalyst-mediated protein aldol ligation (OPAL) that affords stable carbon-c ...[more]