Linchpins empower promiscuous electrophiles to enable site-selective modification of histidine and aspartic acid in proteins.
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ABSTRACT: The conservation of chemoselectivity becomes invalid for multiple electrophilic warheads during protein bioconjugation. Consequently, it leads to unpredictable heterogeneous labeling of proteins. Here, we report that a linchpin can create a unique chemical space to enable site-selectivity for histidine and aspartic acid modifications overcoming the pre-requisite of chemoselectivity.
SUBMITTER: Rawale DG
PROVIDER: S-EPMC8133000 | biostudies-literature |
REPOSITORIES: biostudies-literature
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