Ontology highlight
ABSTRACT:
SUBMITTER: Belle AM
PROVIDER: S-EPMC6050270 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Belle Anna M AM Enright Heather A HA Sales Ana Paula AP Kulp Kristen K Osburn Joanne J Kuhn Edward A EA Fischer Nicholas O NO Wheeler Elizabeth K EK
Scientific reports 20180717 1
Quantitatively benchmarking similarities and differences between the in vivo central nervous system and in vitro neuronal cultures can qualify discrepancies in functional responses and establish the utility of in vitro platforms. In this work, extracellular electrophysiology responses of cortical neurons in awake, freely-moving animals were compared to in vitro cultures of dissociated cortical neurons. After exposure to two well-characterized drugs, atropine and ketamine, a number of key points ...[more]