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The Cucurbit[7]Uril-Based Supramolecular Chemistry for Reversible B/Z-DNA Transition.


ABSTRACT: As a left-handed helical structure, Z-DNA is biologically active and it may be correlated with transcription and genome stability. Until recently, it remained a significant challenge to control the B/Z-DNA transition under physiological conditions. The current study represents the first to reversibly control B/Z-DNA transition using cucurbit[7]uril-based supramolecular approach. It is demonstrated that cucurbit[7]uril can encapsulate the central butanediamine moiety [HN(CH2)4NH] and reverses Z-DNA caused by spermine back to B-DNA. The subsequent treatment with 1-adamantanamine disassembles the cucurbit[7]uril/spermine complex and readily induces reconversion of B- into Z-DNA. The DNA conformational change is unequivocally demonstrated using different independent methods. Direct evidence for supramolecular interactions involved in DNA conformational changes is further provided. These findings can therefore open a new route to control DNA helical structure in a reversible way.

SUBMITTER: Wang SR 

PROVIDER: S-EPMC6051393 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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The Cucurbit[7]Uril-Based Supramolecular Chemistry for Reversible B/Z-DNA Transition.

Wang Shao-Ru SR   Wang Jia-Qi JQ   Xu Guo-Hua GH   Wei Lai L   Fu Bo-Shi BS   Wu Ling-Yu LY   Song Yan-Yan YY   Yang Xi-Ran XR   Li Conggang C   Liu Si-Min SM   Zhou Xiang X  

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20180515 7


As a left-handed helical structure, Z-DNA is biologically active and it may be correlated with transcription and genome stability. Until recently, it remained a significant challenge to control the B/Z-DNA transition under physiological conditions. The current study represents the first to reversibly control B/Z-DNA transition using cucurbit[7]uril-based supramolecular approach. It is demonstrated that cucurbit[7]uril can encapsulate the central butanediamine moiety [HN(CH<sub>2</sub>)<sub>4</su  ...[more]

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