Ontology highlight
ABSTRACT:
SUBMITTER: Bjerregaard-Andersen K
PROVIDER: S-EPMC6052152 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Bjerregaard-Andersen Kaare K Johannesen Hedda H Abdel-Rahman Noha N Heggelund Julie Elisabeth JE Hoås Helene Mykland HM Abraha Fana F Bousquet Paula A PA Høydahl Lene Støkken LS Burschowsky Daniel D Rojas Gertrudis G Oscarson Stefan S Løset Geir Åge GÅ Krengel Ute U
Scientific reports 20180718 1
Targeted cancer immunotherapy offers increased efficacy concomitantly with reduced side effects. One antibody with promising clinical potential is 14F7, which specifically recognises the NeuGc GM3 ganglioside. This antigen is found in the plasma membrane of a range of tumours, but is essentially absent from healthy human cells. 14F7 can discriminate NeuGc GM3 from the very similar NeuAc GM3, a common component of cell membranes. The molecular basis for this unique specificity is poorly understoo ...[more]