Ontology highlight
ABSTRACT:
SUBMITTER: Gully JC
PROVIDER: S-EPMC6052763 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Gully Joseph C JC Sergeyev Valeriy G VG Bhootada Yogesh Y Mendez-Gomez Hector H Meyers Craig A CA Zolotukhin Sergey S Gorbatyuk Marina S MS Gorbatyuk Oleg S OS
Neuroscience letters 20160524
Activating transcription factor 4 (ATF4) is a member of the PERK signaling pathway, which directly binds endoplasmic reticulum stress target genes and plays a crucial role in both adaptations to stress and activation of apoptosis. Previous publications demonstrated conflicting evidence on the role of ATF4 in the pathogenesis of neurodegenerative disorders. In this study, we used recombinant adeno-associate virus (rAAV)-mediated gene transfer to investigate if the sustained up-regulation of ATF4 ...[more]