Ontology highlight
ABSTRACT:
SUBMITTER: Kishimoto S
PROVIDER: S-EPMC6053404 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Kishimoto Shinji S Hara Kodai K Hashimoto Hiroshi H Hirayama Yuichiro Y Champagne Pier Alexandre PA Houk Kendall N KN Tang Yi Y Watanabe Kenji K
Nature communications 20180719 1
The 6,6-quinolone scaffolds on which viridicatin-type fungal alkaloids are built are frequently found in metabolites that display useful biological activities. Here we report in vitro and computational analyses leading to the discovery of a hemocyanin-like protein AsqI from the Aspergillus nidulans aspoquinolone biosynthetic pathway that forms viridicatins via a conversion of the cyclopenin-type 6,7-bicyclic system into the viridicatin-type 6,6-bicyclic core through elimination of carbon dioxide ...[more]