Ontology highlight
ABSTRACT:
SUBMITTER: Elsayed SS
PROVIDER: S-EPMC10728087 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Elsayed Somayah S SS van der Heul Helga U HU Xiao Xiansha X Nuutila Aleksi A Baars Laura R LR Wu Changsheng C Metsä-Ketelä Mikko M van Wezel Gilles P GP
Communications chemistry 20231218 1
Angucyclines are type II polyketide natural products, often characterized by unusual structural rearrangements through B- or C-ring cleavage of their tetracyclic backbone. While the enzymes involved in B-ring cleavage have been extensively studied, little is known of the enzymes leading to C-ring cleavage. Here, we unravel the function of the oxygenases involved in the biosynthesis of lugdunomycin, a highly rearranged C-ring cleaved angucycline derivative. Targeted deletion of the oxygenase gene ...[more]