Genetic variants in SEC16B are associated with body composition in black South Africans.
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ABSTRACT:
SUBMITTER: Sahibdeen V
PROVIDER: S-EPMC6053407 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Genetic variants in SEC16B are associated with body composition in black South Africans.
Sahibdeen Venesa V Crowther Nigel J NJ Soodyall Himla H Hendry Liesl M LM Munthali Richard J RJ Hazelhurst Scott S Choudhury Ananyo A Norris Shane A SA Ramsay Michèle M Lombard Zané Z
Nutrition & diabetes 20180719 1
<h4>Objective</h4>The latest genome-wide association studies of obesity-related traits have identified several genetic loci contributing to body composition (BC). These findings have not been robustly replicated in African populations, therefore, this study aimed to assess whether European BC-associated gene loci played a similar role in a South African black population.<h4>Methods</h4>A replication and fine-mapping study was performed in participants from the Birth to Twenty cohort (N = 1,926) ...[more]
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