Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC6054643 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Zhang Xu X Deeke Shelley A SA Ning Zhibin Z Starr Amanda E AE Butcher James J Li Jennifer J Mayne Janice J Cheng Kai K Liao Bo B Li Leyuan L Singleton Ruth R Mack David D Stintzi Alain A Figeys Daniel D
Nature communications 20180720 1
Alterations in gut microbiota have been implicated in the pathogenesis of inflammatory bowel disease (IBD), however factors that mediate the host-microbiota interactions remain largely unknown. Here we collected mucosal-luminal interface samples from a pediatric IBD inception cohort and characterized both the human and microbiota proteins using metaproteomics. We show that microbial proteins related to oxidative stress responses are upregulated in IBD cases compared to controls. In particular, w ...[more]