Ontology highlight
ABSTRACT:
SUBMITTER: Zhou J
PROVIDER: S-EPMC6055133 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Zhou Jiuli J Zeng Yongji Y Cui Lian L Chen Xingcheng X Stauffer Seth S Wang Zhan Z Yu Fang F Lele Subodh M SM Talmon Geoffrey A GA Black Adrian R AR Chen Yuanhong Y Dong Jixin J
Proceedings of the National Academy of Sciences of the United States of America 20180702 29
Zyxin is a member of the focal adhesion complex and plays a critical role in actin filament polymerization and cell motility. Several recent studies showed that Zyxin is a positive regulator of Yki/YAP (Yes-associated protein) signaling. However, little is known about the mechanisms by which Zyxin itself is regulated and how Zyxin affects Hippo-YAP activity. We first showed that Zyxin is phosphorylated by CDK1 during mitosis. Depletion of Zyxin resulted in significantly impaired colon cancer cel ...[more]