Ontology highlight
ABSTRACT:
SUBMITTER: Baldoni S
PROVIDER: S-EPMC6055653 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Baldoni Stefano S Del Papa Beatrice B Dorillo Erica E Aureli Patrizia P De Falco Filomena F Rompietti Chiara C Sorcini Daniele D Varasano Emanuela E Cecchini Debora D Zei Tiziana T Di Tommaso Ambra A Rosati Emanuela E Alexe Gabriela G Roti Giovanni G Stegmaier Kimberly K Di Ianni Mauro M Falzetti Franca F Sportoletti Paolo P
International journal of cancer 20180323 4
Dysregulated NOTCH1 signaling, by either gene mutations or microenvironment interactions, has been increasingly linked to chronic lymphocytic leukemia (CLL). Thus, inhibiting NOTCH1 activity represents a potential therapeutic opportunity for this disease. Using gene expression-based screening, we identified the calcium channel modulator bepridil as a new NOTCH1 pathway inhibitor. In primary CLL cells, bepridil induced selective apoptosis even in the presence of the protective stroma. Cytotoxic e ...[more]