Ontology highlight
ABSTRACT:
SUBMITTER: Dekkers CCJ
PROVIDER: S-EPMC6055757 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Dekkers Claire C J CCJ Petrykiv Sergei S Laverman Gozewijn D GD Cherney David Z DZ Gansevoort Ron T RT Heerspink Hiddo J L HJL
Diabetes, obesity & metabolism 20180423 8
The mechanisms by which SGLT-2 inhibitors lower albuminuria are incompletely understood. We assessed in a post-hoc analysis of a cross-over trial the effects of the SGLT2 inhibitor dapagliflozin on glomerular markers (IgG to IgG4 and IgG to albumin), tubular markers (urinary KIM-1, NGAL and LFABP) and inflammatory markers (urinary MCP-1 and IL-6) to provide more insight into kidney protective effects. Dapagliflozin decreased albuminuria by 43.9% (95% CI, 30.3%-54.8%) and eGFR by 5.1 (2.0-8.1) mL ...[more]