Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC6056247 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Wang Yongliang Y Nasiri Ali R AR Damsky William E WE Perry Curtis J CJ Zhang Xian-Man XM Rabin-Court Aviva A Pollak Michael N MN Shulman Gerald I GI Perry Rachel J RJ
Cell reports 20180701 1
Obesity is associated with colon cancer pathogenesis, but the underlying mechanism is actively debated. Here, we confirm that diet-induced obesity promotes tumor growth in two murine colon cancer models and show that this effect is reversed by an orally administered controlled-release mitochondrial protonophore (CRMP) that acts as a liver-specific uncoupler of oxidative phosphorylation. This agent lowered circulating insulin, and the reduction of tumor growth was abrogated by an insulin infusion ...[more]